The Clever Badger One lab accident away from being a super villain

20Jun/103

Book Review – The Poisoner’s Handbook by Deborah Blum

A few weeks ago, a copy of The Poisoner's Handbook by Deborah Blum ended up in my grubby little paws.

Blum, who describes herself as a lapsed chemist, has put together a fascinating book that is equal parts crime drama, chemistry lesson, and history book.

Blum follows the development of forensics as a legitimate discipline in New York City during the Prohibition Era by Charles Morris and Andrew Gettler.

Much of the work of Morris and Gettler involved developing new or more reliable techniques to detect the numerous poisons that tended to turn up in people of the era.  Apart from the various adulterants in Prohibition booze (kerosene, mercury, and Lysol were known to turn up, and as Prohibition dragged on, the Government actively developed new formulas to ensure that industrial alcohol couldn't be used to make booze), such delightful poisons such as cyanides, carbon monoxide, radium, and thallium were used to put spouses, lovers, business associates, and random people into the ground.   An interesting observation that I hadn't made before but should have is that a lot of poisons are deadly because they chemically resemble things that are supposed to be in our bodies but are more reactive.  This allows the poisons to interfere with normal physiological processes - for example carbon monoxide binds to hemoglobin in the blood more tightly than oxygen - with predictably deadly results.

Blum's research into the details of each substance allows her to give detailed descriptions of the effects of each poison, and her blunt narration of the techniques necessary to isolate those poisons from cadavers would make for interesting dinner conversation (apparently the first step is often to mince brain tissue into a paste...).

Her account of the political obstacles Norris and Gettler had to deal with just to obtain and maintain funding for their department make it seem all the more remarkable that they were able to accomplish the groundbreaking work that they did.  Norris used many of his personal resources to provision and operate his laboratory.

To give much more detail would be to ruin the fun of the book.  I highly recommend The Poisoner's Handbook to anyone with an interest in medical detective work or in the details of early 20th Century American history.  For those who might want a rating, I give this book five skulls and crossbones out of five.

-Jay

21May/1010

In Which The Badger Tries Valiantly To Read The Lost Symbol

I read Dan Brown's first four novels in relatively quick succession.  They were all at least moderately  engaging despite their flaws, and The Da Vinci Code is one of three novels that I have read at one sitting with breaks only to do necessary things like feed the kids.  (The others were Tolkien's The Hobbit and Tom Clancy's The Hunt For Red October, if anyone cares.)

Brown's novels attempt to incorporate real technologies and history into their fictional settings, although Brown often takes some fairly liberal license with things.  That's usually forgiveable if the surrounding narrative is engaging.  Brown also tends to rely on his characters doing fairly unlikely things in key situations.  That's something that sticks out like a tusk on a narwhal when I see it.

For example, in Digital Fortress,  the climax to the book depends on a room full of very intelligent people suddenly becoming complete idiots at the same time.  All of them.  In response to a riddle that I answered before I'd read the entire thing.  That kind of awkward plot contrivance sucks the life out of a story faster than a swarm of mosquitoes can drain a moose.

Angels and Demons was better, but in the end relied on what amounted to superhuman abilities on the part of the Langdon character to resolve a key plot element.  It wasn't quite as jarring as Digital Fortress, but it was pretty close.

The Da Vinci Code was probably Brown's best work, despite being based on what I can most charitably call complete bullshit.  There was a lot of controversy around the book when it came out because of the way it portrayed Christianity in general, and a lot of people got really spun up about the liberties that Brown took with "facts", when in reality he was taking liberties with bullshit that had already parted ways with most of what anyone actually regards as historical fact.  So, if you were offended by The Da Vinci Code, it's probably high time you got over it and move on.

Anyhow, Brown's new book, The Lost Symbol takes the hero of the last two books, Robert Langdon, and plonks him down in Washington, D.C. in the middle of a mystery that involves the Freemasons. 

D.C. is a fascinating city, and certainly makes a good setting for a mystery/thriller.  The Masons make a good secretive society to weave a story around - no problems so far. 

But the plot device that hit me like a spiked bowling ball dropped in my lap from the top of a tall building is the concept of Noetic Science that is starting to get woven into the plot.  Noetic Science, near as I can tell, is pretty much an umbrella under which congregates a lot of things that I would, again with great charity, call bullshit.  The Wikipedia page talks about things like "studies on the efficacy of compassionate intention on healing AIDS patients."  Ooooooo-kay. 

The introduction of Noetic Science into The Lost Symbol effectively means that I'll be reading the rest of the book with a tiny voice in the back of my head whispering bullshit! the whole time. 

Not good. 

It's probably a reflection on myself that I can suspend my disbelief thoroughly enough to be immersed in, say, Tolkien's Middle Earth, but I can't let myself buy into the notion of Noetic Science for the duration of one book, so for the sake of argument I'll make a conscious effort to ignore my tiny whispering voice for the remainder of the book.

(NOTE:  I'll mention here that Brown gets a lot of heat from far better critics than me for what can best be described as clumsy writing.  I don't disagree in the sense that he does know how to mix up a world-class bowl of word salad, particularly when he over-describes characters.  At the same time, I suspect that Brown is well aware that he's writing what he hopes will be popular, best-selling books that appeal to a wide variety of readers.  To that extent, his style of writing probably serves him well.  (I did, after all, read The Da Vinci Code in a day, so his style clearly wasn't so onerous that it made me put the book down...)  An engaging story can often overcome an awkward writing style.)

I'm going to make a push to complete The Lost Symbol, mainly because I hate to leave a book unfinished, but I'm not sure I can get past Noetic Science...

-Jay

3May/102

Book Review: The Immortal Life of Henrietta Lacks, by Rebecca Skloot

The first eBook I purchased for my new Kindle was Rebecca Skloot's The Immortal Life of Henrietta Lacks. 

I'd seen The Immortal Life mentioned on ScienceBlogs - a lot - and had intended to pick it up in hardcopy for a while and for some reason never got around to it.  Sitting in an airport last week with some time on my hands before my flight boarded ended up being the perfect opportunity to test out the Kindle's wireless delivery and to pick up Rebecca's book.

If you only read one book this year, you should read The Immortal Life of Henrietta Lacks.

By way of background, Henrietta Lacks was an African-American woman who was diagnosed with cervical cancer in early 1951 at Johns Hopkins.  During part of her treatment, cells from the carcinoma were taken to be used for research purposes.  Mrs. Lacks was unaware of this - obtaining informed consent from patients wasn't typical practice in 1951 - and died in October of 1951 without knowing the impact those cells would have.

The cell line originating from the sample taken from Mrs. Lacks is known as HeLa (named based on the first two letters of her first and last name).  HeLa, for reasons that aren't important for this short review, are pretty much immortal - they keep dividing without regard for the Hayflick limit, and consequently are valuable for research.  Odds are that you've had some sort of medical treatment that either directly or indirectly made use of HeLa during the course of its development.

The story of the cell line would be interesting enough on its own, but Skloot goes much deeper - uncovering the history of the Lacks family, revealing the human effects of racial segregation in medicine, and confronting the reader with many of the ethical and financial considerations of tissue research - telling the story from the perspective of the investigations she did with Henrietta's daughter, Deborah.1

The discussions of the scientific and medical importance of HeLa is fascinating. The image painted of the life of a poor African-American family living in the shadow of the nation's capital is stark, particularly when you realize that the conditions now are in many ways similar to the way they were circa 1951.  The frank accounts of the anger, mistrust, and confusion of the Lacks family over how Hopkins in particular and medical science in general acquired and made use of Henrietta's cells are riveting and often heart-wrenching.

Rebecca Skloot's sensitivity and meticulous attention to detail are evident throughout the book.  Her care and compassion for the Lacks family are clear - just look at the photos on her website.  The Immortal Life of Henrietta Lacks is a book that she had to write.

And it's a book that's well worth your time to read.

-Jay
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1In wrapping up the book, Skloot notes the passing of a number of the Lacks family members and friends, including Deborah. It struck me that had she waited much longer to start her project, Rebecca would have found some of her most valuable resources lost to history.

Filed under: Book Review 2 Comments
7Nov/099

I Love Getting New Books

(Image via The Jewish Publication Society)

(Image via The Jewish Publication Society)

Yesterday1 I received my copy of Judy Klitsner's Subversive Sequels In The Bible: How Biblical Stories Mine and Undermine Each Other.  (Thanks to James McGrath for mentioning this book on his blog.)

There is a lot of discussion about contradictions and other inconsistencies in the Bible.  This is because the Bible is chock-full of such inconsistencies.  Some of them are minor, but many of them are quite significant.2

I think it's very important to acknowledge and try to understand those inconsistencies, since they reflect the very human composition of the Bible, and can give us important insights into the views and intentions of the generally anonymous authors whose works we are reading.  (I also think that any sort of legitimate Bible study needs to give a lot of consideration to the social context in which the material was written and to the goals and intentions of the writers, rather than simply asking "what was God trying to tell us?".  That's a topic for another post, though.)

In any event, I'm moving Subversive Sequels to the top of my reading stack, and hope to get a review up within the next week, give or take.

Jay

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1Barely yesterday. I'm writing this at about 2 AM, having been woken up half an hour ago by my cat announcing that she was hungry.  My cat is not svelte - surely she could have endured another few hours on stored non-sveltness before she had to wake me up...

2There are a number of books dealing with this subject matter. A few on my shelf are: The Bible Against Itself: Why The Bible Seems To Contradict Itself by Randel McCraw Helms, 101 Myths of the Bible: How Ancient Scribes Invented Biblical History by Gary Greenberg, and R.E. Friedman's Who Wrote the Bible.

24Oct/0911

Illustrating a Point, Continued

A couple of weeks back, I wrote a post discussing (among other things) Russ Pulliam's Indianapolis Star opinion piece, Taking Darwin on Faith.

Mr. Pulliam has written another piece, Darwin debates, Part 2,  in which he attempts to address some of the concerns I expressed, as well as some of those pointed out by James McGrath.  (He didn't mention Rev. Ouabache's comments, for some reason.)

Before I get to his comments about my article, I want to touch on something that struck me as very intriguing.

In the introduction to his most recent opinion piece, Mr. Pulliam writes:

To celebrate the 150th anniversary of the publication of Charles Darwin's "Origin of Species," I recently wrote an objection to the belief that Darwin's theory can be used an explanation for the origins of the universe.

I've read and re-read Mr. Pulliam's original piece, and quite frankly I do not think that this is true.  In his original opinion, Mr. Pulliam cited Richard Holdeman's (correct) comments that science does not answer questions about the meaning and purpose of the universe.  That's a fairly obvious and non-controversial statement.1,2

When Mr. Pulliam mentions the universe, it's in an illustrative manner in what appears to be a broader context lamenting the lack of philosophical (i.e. theological) considerations in science.

Now, turning to his comments on my post, he writes:

If blogger Clever Badger were to open a school, I probably wouldn't gain admission. He lumps me in with the young Earth creationists and faults me for oversimplifying evolution as humans coming from amoebas. I plead guilty to oversimplification.

He misunderstood my comment about the definition of science as observation and experimentation. "So Pulliam wants us to redefine science?"

I never said that, but he caught my main point. "If you get too far away from that, you aren't doing science any more. You're doing some sort of philosophy."

To which I say "Amen."

I'll address these comments one by one.

1)If blogger Clever Badger were to open a school, I probably wouldn't gain admission.

Sure he would.  Were I to open a school, I wouldn't base my admissions on whether or not applicants agreed with everything I taught.  I would expect students to learn the material and understand it, but understanding doesn't automatically imply agreement.

2)He lumps me in with the young Earth creationists...

Given that Mr. Pulliam invokes several very common Young Earth Creationist concepts in his article, it's natural to lump him in that way.  He makes no effort in his follow-up piece to correct my assumption.  If it walks like a duck, and quacks like a duck...

3)...and faults me for oversimplifying evolution as humans coming from amoebas. I plead guilty to oversimplification.

Actually the term I used was "bullshit".  Such an "oversimplification" is nothing to brag about.  It strongly implies that Mr. Pulliam does not know what he's talking about when discussing evolution, and has no business trying to explain it to anyone.  It's one thing to omit details of a subject in order to get across an essential concept.  It's another thing entirely to omit so much detail that the subject matter becomes unrecognizable.

4)He misunderstood my comment about the definition of science as observation and experimentation. "So Pulliam wants us to redefine science?"

I won't deny that I might have misinterpreted Mr. Pulliam's comment.  It's entirely possible that he meant something completely different with the statement "(p)art of the problem is defining science, which is traditionally limited to observation and experimentation." If he did, he didn't bother to explain himself in his most recent article, nor (as of 24 October 2009) has he addressed the matter in the comments at the Indianapolis Star website.

5)I never said that, but he caught my main point. "If you get too far away from that, you aren't doing science any more. You're doing some sort of philosophy."  To which I say "Amen."

This statement seems to suggest that Mr. Pulliam wants more philosophical overtones in his science, which seems consistent with the overall tone of his first article.  An odd thing, though, is that towards the end of his first article, Mr. Pulliam states the following:

The debate has become as much about philosophy and politics than science. Followers of Darwin have won many of the arguments at a political level, cloaking their philosophy under the banner of science.

This statement leaves me scratching my head.  Is Pulliam indicating that philosophy and science should be separate? I suspect that what he's actually trying to do is implicitly assert as fact the (bogus) claim he made earlier in that first opinion piece - "(y)et there's a leap of faith involved in Darwinian theory" - and then imply that since scientists (by which I think he really wants to say biologists) are already working on faith, then there isn't a problem layering explicitly religious philosophies onto science.

The sad thing here is that Pulliam had an opportunity in his second article to correct what he thinks are misinterpretations made by James McGrath and me, but he would apparently rather use the space allocated to him to whine about the fact that we called him out on his poor understanding of science (in general) and evolution (in particular).

Maybe next time.

Jay

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1In the original piece, there is an editorial mistake. As printed, the paragraph reads thus:

What troubles Holdeman is how some followers of Darwin have taken his work and turned it into a theological treatise about the origins and purpose of the universe. "Science by nature does not answer questions related to meaning and purpose in the universe." he said. "It is wrong to use science to justify what are essentially religious beliefs. The result is that many religious people are offended by and reject evolution because of its supposed religious implications rather than its scientific merits or lack thereof.

There is a missing end quote that should appear either after the word "beliefs" or at the very end of the paragraph. Without that quote, the reader can't distinguish whether "(t)he result is that many religious people are offended by and reject evolution because of its supposed religious implications rather than its scientific merits or lack thereof " is part of Holdeman's comment or Pulliam's gloss on Holdeman's comment.  I'm making the assumption that it's Holdeman's.

2The statement that Pulliam makes about some "followers of Darwin" (I really dislike that term) taking Darwin's work and using it to explain the origin of the universe is kind of tricky.  While it is true that there are probably some people who improperly extrapolate evolutionary theory into the realm of cosmology, nobody who really understands what they're talking about does that.  If Mr. Pulliam believes that the problem is widespread within the community of working biologists, he's simply incorrect.

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